Melanoma NOS1 expression promotes dysfunctional IFN signaling

In multiple forms of cancer, constitutive activation of type I IFN signaling is a critical consequence of immune surveillance against cancer; however, PBMCs isolated from cancer patients exhibit depressed STAT1 phosphorylation in response to IFN-α, suggesting IFN signaling dysfunction. Here, we demo...

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Detaylı Bibliyografya
Asıl Yazarlar: Liu, Qiuzhen, Tomei, Sara, Ascierto, Maria Libera, De Giorgi, Valeria, Bedognetti, Davide, Dai, Cuilian, Uccellini, Lorenzo, Spivey, Tara, Pos, Zoltan, Thomas, Jaime, Reinboth, Jennifer, Murtas, Daniela, Zhang, Qianbing, Chouchane, Lotfi, Weiss, Geoffrey R., Slingluff, Craig L., Lee, Peter P., Rosenberg, Steven A., Alter, Harvey, Yao, Kaitai, Wang, Ena, Marincola, Francesco M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001531/
https://ncbi.nlm.nih.gov/pubmed/24691438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69611
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