Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

Thrombopoietin (TPO) acting via its receptor, the cellular homologue of the myeloproliferative leukemia virus oncogene (Mpl), is the major cytokine regulator of platelet number. To precisely define the role of specific hematopoietic cells in TPO-dependent hematopoiesis, we generated mice that expres...

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Autores principales: Ng, Ashley P., Kauppi, Maria, Metcalf, Donald, Hyland, Craig D., Josefsson, Emma C., Lebois, Marion, Zhang, Jian-Guo, Baldwin, Tracey M., Di Rago, Ladina, Hilton, Douglas J., Alexander, Warren S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000844/
https://ncbi.nlm.nih.gov/pubmed/24711413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404354111
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