p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer

Anaplastic thyroid carcinoma (ATC) has among the worst prognoses of any solid malignancy. The low incidence of the disease has in part precluded systematic clinical trials and tissue collection, and there has been little progress in developing effective therapies. v-raf murine sarcoma viral oncogene...

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Bibliografiske detaljer
Main Authors: McFadden, David G., Vernon, Amanda, Santiago, Philip M., Martinez-McFaline, Raul, Bhutkar, Arjun, Crowley, Denise M., McMahon, Martin, Sadow, Peter M., Jacks, Tyler
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000830/
https://ncbi.nlm.nih.gov/pubmed/24711431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404357111
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