Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes

Pancreatic β cell failure leads to diabetes development. During disease progression, β cells adapt their secretory capacity to compensate the elevated glycaemia and the peripheral insulin resistance. This compensatory mechanism involves a fine-tuned regulation to modulate the endoplasmic reticulum (...

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Main Authors: Rabhi, Nabil, Salas, Elisabet, Froguel, Philippe, Annicotte, Jean-Sébastien
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2014
Teme:
Review Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000654/
https://ncbi.nlm.nih.gov/pubmed/24812634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/795171
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