Genetic Validation of Aminoacyl-tRNA Synthetases as Drug Targets in Trypanosoma brucei

Human African trypanosomiasis (HAT) is an important public health threat in sub-Saharan Africa. Current drugs are unsatisfactory, and new drugs are being sought. Few validated enzyme targets are available to support drug discovery efforts, so our goal was to obtain essentiality data on genes with pr...

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Main Authors: Kalidas, Savitha, Cestari, Igor, Monnerat, Severine, Li, Qiong, Regmi, Sandesh, Hasle, Nicholas, Labaied, Mehdi, Parsons, Marilyn, Stuart, Kenneth, Phillips, Margaret A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000095/
https://ncbi.nlm.nih.gov/pubmed/24562907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00017-14
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