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Genetic Validation of Aminoacyl-tRNA Synthetases as Drug Targets in Trypanosoma brucei
Human African trypanosomiasis (HAT) is an important public health threat in sub-Saharan Africa. Current drugs are unsatisfactory, and new drugs are being sought. Few validated enzyme targets are available to support drug discovery efforts, so our goal was to obtain essentiality data on genes with pr...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4000095/ https://ncbi.nlm.nih.gov/pubmed/24562907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00017-14 |
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