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Antibody-modified T cells: CARs take the front seat for hematologic malignancies

T cells redirected to specific antigen targets with engineered chimeric antigen receptors (CARs) are emerging as powerful therapies in hematologic malignancies. Various CAR designs, manufacturing processes, and study populations, among other variables, have been tested and reported in over 10 clinic...

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Autori principali: Maus, Marcela V., Grupp, Stephan A., Porter, David L., June, Carl H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999751/
https://ncbi.nlm.nih.gov/pubmed/24578504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-11-492231
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