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Structure-Based Evaluation of C5 Derivatives in the Catechol Diether Series Targeting HIV-1 Reverse Transcriptase
Using a computationally driven approach, a class of inhibitors with picomolar potency known as the catechol diethers were developed targeting the non-nucleoside binding pocket (NNBP) of HIV-1 RT. Computational studies suggested that halogen bonding interactions between the C5 substituent of the inhi...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3999282/ https://ncbi.nlm.nih.gov/pubmed/24289305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12266 |
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