New Genetic Biomarkers Predicting Azathioprine Blood Concentrations in Combination Therapy with 5-Aminosalicylic Acid

BACKGROUND AND AIMS: Azathioprine (AZA) is widely used for the treatment of inflammatory bowel disease (IBD) patients. AZA is catabolized by thiopurine S-methyltransferase (TPMT), which exhibits genetic polymorphisms. It has also been reported that 5-aminosalicylic acid (5-ASA) inhibits TPMT activit...

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Detalhes bibliográficos
Main Authors: Uchiyama, Kazuhiko, Takagi, Tomohisa, Iwamoto, Yasunori, Kondo, Norihiko, Okayama, Tetsuya, Yoshida, Naohisa, Kamada, Kazuhiro, Katada, Kazuhiro, Handa, Osamu, Ishikawa, Takeshi, Yasuda, Hiroaki, Sakagami, Junichi, Konishi, Hideyuki, Yagi, Nobuaki, Naito, Yuji, Itoh, Yoshito
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999094/
https://ncbi.nlm.nih.gov/pubmed/24762746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095080
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