Intradermal delivery of Shigella IpaB and IpaD type III secretion proteins: Kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity, and protection across serotypes

Shigella is one of the leading pathogens contributing to the vast pediatric diarrheal disease burden in low-income countries. No licensed vaccine is available and the existing candidates are only partially effective and serotype-specific. Shigella type III secretion system proteins IpaB and IpaD, wh...

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Detalhes bibliográficos
Main Authors: Heine, Shannon J., Diaz-McNair, Jovita, Andar, Abhay U., Drachenberg, Cinthia B., van de Verg, Lillian, Walker, Richard, Picking, Wendy L., Pasetti, Marcela F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3998105/
https://ncbi.nlm.nih.gov/pubmed/24453241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302743
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