PD-0332991 induces G1 arrest of colorectal carcinoma cells through inhibition of the cyclin-dependent kinase-6 and retinoblastoma protein axis

Preclinical and clinical studies have demonstrated the anticancer activity of PD-0332991, a selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, in the treatment of various types of cancer in a retinoblastoma protein (RB)-dependent manner. However, it remains unclear whether CDK4, CDK6 or both...

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Main Authors: LI, CHUNSHENG, QI, LING, BELLAIL, ANITA C., HAO, CHUNHAI, LIU, TONGJUN
Formato: Artigo
Idioma:Inglês
Publicado: D.A. Spandidos 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997702/
https://ncbi.nlm.nih.gov/pubmed/24765199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2014.1957
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