Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz’s role in ethanol withdrawal and support its role in voluntary ethanol consumption

Association studies implicate multiple PDZ domain protein (MPDZ/MUPP1) sequence and/or expression in risk for alcoholism in humans and ethanol withdrawal (EW) in mice, but confirmation has been hindered by the dearth of targeted genetic models. We report the creation of transgenic (MPDZ-TG) and knoc...

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Autori principali: Milner, Lauren C., Shirley, Renee L., Kozell, Laura B., Walter, Nicole A., Kruse, Lauren C., Komiyama, Noboru H., Grant, Seth G.N., Buck, Kari J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997615/
https://ncbi.nlm.nih.gov/pubmed/24118405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12087
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