Mapping a Barbiturate Withdrawal Locus to a 0.44 Mb Interval and Analysis of a Novel Null Mutant Identify a Role for Kcnj9 (GIRK3) in Withdrawal from Pentobarbital, Zolpidem, and Ethanol

Here, we map a quantitative trait locus (QTL) with a large effect on predisposition to barbiturate (pentobarbital) withdrawal to a 0.44 Mb interval of mouse chromosome 1 syntenic with human 1q23.2. We report a detailed analysis of the genes within this interval and show that it contains 15 known and...

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Autori principali: Kozell, Laura B., Walter, Nicole A. R., Milner, Lauren C., Wickman, Kevin, Buck, Kari J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2009
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813520/
https://ncbi.nlm.nih.gov/pubmed/19759313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1413-09.2009
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