Adenoviruses Using the Cancer Marker EphA2 as a Receptor In Vitro and In Vivo by Genetic Ligand Insertion into Different Capsid Scaffolds

Adenoviral gene therapy and oncolysis would critically benefit from targeted cell entry by genetically modified capsids. This requires both the ablation of native adenovirus tropism and the identification of ligands that remain functional in virus context. Here, we establish cell type-specific entry...

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Hlavní autoři: Behr, Michael, Kaufmann, Johanna K., Ketzer, Patrick, Engelhardt, Sarah, Mück-Häusl, Martin, Okun, Pamela M., Petersen, Gabriele, Neipel, Frank, Hassel, Jessica C., Ehrhardt, Anja, Enk, Alexander H., Nettelbeck, Dirk M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997477/
https://ncbi.nlm.nih.gov/pubmed/24760010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095723
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