Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase

BACKGROUND AND PURPOSE: 1,4-Benzoquinones are well-known inhibitors of 5-lipoxygenase (5-LOX, the key enzyme in leukotriene biosynthesis), but the molecular mechanisms of 5-LOX inhibition are not completely understood. Here we investigated the molecular mode of action and the pharmacological profile...

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Detalles Bibliográficos
Main Authors: Schaible, A M, Filosa, R, Temml, V, Krauth, V, Matteis, M, Peduto, A, Bruno, F, Luderer, S, Roviezzo, F, Di Mola, A, Rosa, M, D'Agostino, B, Weinigel, C, Barz, D, Koeberle, A, Pergola, C, Schuster, D, Werz, O
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997279/
https://ncbi.nlm.nih.gov/pubmed/24467325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12592
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