CXCL12 in astrocytes contributes to bone cancer pain through CXCR4-mediated neuronal sensitization and glial activation in rat spinal cord

BACKGROUND: Previous studies have demonstrated that chemokine CXCL12 and its receptor CXCR4 are critical for pain sensitization, but the mechanisms involved are not clear. In this study, we investigated the specific cellular mechanisms of CXCL12/CXCR4 chemokine signaling in the development and maint...

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Detalhes bibliográficos
Main Authors: Shen, Wen, Hu, Xue-Ming, Liu, Yan-Nan, Han, Yuan, Chen, Li-Ping, Wang, Chen-Chen, Song, Chao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3996502/
https://ncbi.nlm.nih.gov/pubmed/24735601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-75
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