Elimination of inter-domain interactions increases the cleavage fidelity of the restriction endonuclease DraIII

DraIII is a type IIP restriction endonucleases (REases) that recognizes and creates a double strand break within the gapped palindromic sequence CAC↑NNN↓GTG of double-stranded DNA (↑ indicates nicking on the bottom strand; ↓ indicates nicking on the top strand). However, wild type DraIII shows signi...

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Bibliographic Details
Main Authors: Zhuo, Wei, Lai, Xuhui, Zhang, Liqing, Chan, Siu-Hong, Li, Fengjuan, Zhu, Zhenyu, Yang, Maojun, Sun, Dapeng
Format: Artigo
Language:Inglês
Published: Higher Education Press 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3996161/
https://ncbi.nlm.nih.gov/pubmed/24733184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-014-0038-z
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