Site-specific Labeling of a Protein Lysine Residue By Novel Kinetic Labeling Combinatorial Libraries

The first example of a kinetic labeling library designed to enable the discovery of affinity labels is presented. Each library component (1) consists of a variable peptidyl component linked to a biotinyl moiety by a 4-mercaptobenzoyl linker in thioester format. We demonstrate that an affinity label...

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Main Authors: Krantz, Allen, Hanel, Arthur M, Strug, Ivona, Wilczynski, Andrzej, Wolff, Jeremy J, Huang, Wolin, Huang, Linda H, Settineri, Tina, Holmes, Darren L, Hardy, Margaret C, Bridon, Dominique P
Format: Artigo
Jezik:Inglês
Izdano: Research Network of Computational and Structural Biotechnology (RNCSB) Organization 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3995232/
https://ncbi.nlm.nih.gov/pubmed/24757504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5936/csbj.201403001
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