KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun

Loss-of-function mutations in the KRIT1 gene (CCM1) have been associated with the pathogenesis of cerebral cavernous malformations (CCM), a major cerebrovascular disease. However, KRIT1 functions and CCM pathogenetic mechanisms remain incompletely understood. Indeed, recent experiments in animal mod...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Goitre, Luca, De Luca, Elisa, Braggion, Stefano, Trapani, Eliana, Guglielmotto, Michela, Biasi, Fiorella, Forni, Marco, Moglia, Andrea, Trabalzini, Lorenza, Retta, Saverio Francesco
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Science 2014
Materias:
Original Contributions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994518/
https://ncbi.nlm.nih.gov/pubmed/24291398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.11.020
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares