Nanosuspension delivery of paclitaxel to xenograft mice can alter drug disposition and anti-tumor activity

Paclitaxel is a common chemotherapeutic agent that is effective against various cancers. The poor aqueous solubility of paclitaxel necessitates a large percentage of Cremophor EL:ethanol (USP) in its commercial formulation which leads to hypersensitivity reactions in patients. We evaluate the use of...

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Autors principals: Chiang, Po-Chang, Gould, Stephen, Nannini, Michelle, Qin, Ann, Deng, Yuzhong, Arrazate, Alfonso, Kam, Kimberly R, Ran, Yingqing, Wong, Harvey
Format: Artigo
Idioma:Inglês
Publicat: Springer 2014
Matèries:
Nano Commentary
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994220/
https://ncbi.nlm.nih.gov/pubmed/24685243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1556-276X-9-156
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