Development of a Cell-Based Assay Measuring the Activation of FcγRIIa for the Characterization of Therapeutic Monoclonal Antibodies

Antibody-dependent cellular cytotoxicity (ADCC) is one of the important mechanisms of action of the targeting of tumor cells by therapeutic monoclonal antibodies (mAbs). Among the human Fcγ receptors (FcγRs), FcγRIIIa is well known as the only receptor expressed in natural killer (NK) cells, and it...

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Main Authors: Tada, Minoru, Ishii-Watabe, Akiko, Suzuki, Takuo, Kawasaki, Nana
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994145/
https://ncbi.nlm.nih.gov/pubmed/24752341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095787
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