The Absence of CpG in Plasmid DNA–Chitosan Polyplexes Enhances Transfection Efficiencies and Reduces Inflammatory Responses in Murine Lungs

[Image: see text] Chitosan polyplexes containing plasmid DNA (pDNA) have significant potential for pulmonary gene delivery applications. However, prior to using chitosan/pDNA polyplexes (CSpp) in clinical applications, their potential cytotoxicity needs to be investigated. In this study, we formulat...

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Detalhes bibliográficos
Main Authors: Wongrakpanich, Amaraporn, Adamcakova-Dodd, Andrea, Xie, Wei, Joshi, Vijaya B., Mapuskar, Kranti A., Geary, Sean M., Spitz, Douglas R., Thorne, Peter S., Salem, Aliasger K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993893/
https://ncbi.nlm.nih.gov/pubmed/24494979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp400689r
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