The Rpe65(rd12) Allele Exerts a Semidominant Negative Effect on Vision in Mice

PURPOSE. The rd12 mouse was reported as a recessively inherited Rpe65 mutation. We asked if the rd12 mutation resides in Rpe65 and how the mutation manifests itself. METHODS. A complementation test was performed by mating Rpe65(KO) (KO/KO) and rd12 mice together to determine if the rd12 mutation is...

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Autori principali: Wright, Charles B., Chrenek, Micah A., Feng, Wei, Getz, Shannon E., Duncan, Todd, Pardue, Machelle T., Feng, Yue, Redmond, T. Michael, Boatright, Jeffrey H., Nickerson, John M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993890/
https://ncbi.nlm.nih.gov/pubmed/24644049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13574
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