Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response

RIG-I is a cytosolic sensor critically involved in the activation of the innate immune response to RNA virus infection. In the present study, we evaluated the inhibitory effect of a RIG-I agonist on the replication of two emerging arthropod-borne viral pathogens, dengue virus (DENV) and chikungunya...

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Main Authors: Olagnier, David, Scholte, Florine E. M., Chiang, Cindy, Albulescu, Irina C., Nichols, Carmen, He, Zhong, Lin, Rongtuan, Snijder, Eric J., van Hemert, Martijn J., Hiscott, John
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993760/
https://ncbi.nlm.nih.gov/pubmed/24478443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03114-13
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