Flexibility in Surface-Exposed Loops in a Virus Capsid Mediates Escape from Antibody Neutralization

New human norovirus strains emerge every 2 to 3 years, partly due to mutations in the viral capsid that allow escape from antibody neutralization and herd immunity. To understand how noroviruses evolve antibody resistance, we investigated the structural basis for the escape of murine norovirus (MNV)...

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Detalhes bibliográficos
Main Authors: Kolawole, Abimbola O., Li, Ming, Xia, Chunsheng, Fischer, Audrey E., Giacobbi, Nicholas S., Rippinger, Christine M., Proescher, Jody B. G., Wu, Susan K., Bessling, Seneca L., Gamez, Monica, Yu, Chenchen, Zhang, Rebecca, Mehoke, Thomas S., Pipas, James M., Wolfe, Joshua T., Lin, Jeffrey S., Feldman, Andrew B., Smith, Thomas J., Wobus, Christiane E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993751/
https://ncbi.nlm.nih.gov/pubmed/24501415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03685-13
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