Epstein-Barr Virus Essential Antigen EBNA3C Attenuates H2AX Expression

Epstein-Barr virus (EBV) latent antigen EBNA3C is implicated in B-cell immortalization and linked to several B-cell malignancies. Deregulation of H2AX can induce genomic instability with increased chromosomal aberrations, which ultimately leads to tumorigenesis. Here we demonstrated that EBNA3C can...

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Bibliographic Details
Main Authors: Jha, Hem C., AJ, Mahadesh Prasad, Saha, Abhik, Banerjee, Shuvomoy, Lu, Jie, Robertson, Erle S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993541/
https://ncbi.nlm.nih.gov/pubmed/24429368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03568-13
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