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Epigenetic silencing of tumor suppressor genes during in vitro Epstein–Barr virus infection

DNA-methylation at CpG islands is one of the prevalent epigenetic alterations regulating gene-expression patterns in mammalian cells. Hypo- or hypermethylation-mediated oncogene activation, or tumor suppressor gene (TSG) silencing mechanisms, widely contribute to the development of multiple human ca...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Saha, Abhik, Jha, Hem C., Upadhyay, Santosh K., Robertson, Erle S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577197/
https://ncbi.nlm.nih.gov/pubmed/26324942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503806112
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