Evolution of a Cell Culture-Derived Genotype 1a Hepatitis C Virus (H77S.2) during Persistent Infection with Chronic Hepatitis in a Chimpanzee

Persistent infection is a key feature of hepatitis C virus (HCV). However, chimpanzee infections with cell culture-derived viruses (JFH1 or related chimeric viruses that replicate efficiently in cell culture) have been limited to acute-transient infections with no pathogenicity. Here, we report pers...

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Bibliographische Detailangaben
Hauptverfasser: Yi, MinKyung, Hu, Fengyu, Joyce, Michael, Saxena, Vikas, Welsch, Christoph, Chavez, Deborah, Guerra, Bernadette, Yamane, Daisuke, Veselenak, Ronald, Pyles, Rick, Walker, Christopher M., Tyrrell, Lorne, Bourne, Nigel, Lanford, Robert E., Lemon, Stanley M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993530/
https://ncbi.nlm.nih.gov/pubmed/24429362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03540-13
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