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T-bet Regulates Immunity to Francisella tularensis Live Vaccine Strain Infection, Particularly in Lungs

Upregulation of the transcription factor T-bet is correlated with the strength of protection against secondary challenge with the live vaccine strain (LVS) of Francisella tularensis. Thus, to determine if this mediator had direct consequences in immunity to LVS, we examined its role in infection. De...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Melillo, Amanda A., Foreman, Oded, Bosio, Catharine M., Elkins, Karen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993391/
https://ncbi.nlm.nih.gov/pubmed/24421047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01545-13
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