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T-bet Regulates Immunity to Francisella tularensis Live Vaccine Strain Infection, Particularly in Lungs

Upregulation of the transcription factor T-bet is correlated with the strength of protection against secondary challenge with the live vaccine strain (LVS) of Francisella tularensis. Thus, to determine if this mediator had direct consequences in immunity to LVS, we examined its role in infection. De...

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Hlavní autoři: Melillo, Amanda A., Foreman, Oded, Bosio, Catharine M., Elkins, Karen L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993391/
https://ncbi.nlm.nih.gov/pubmed/24421047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01545-13
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