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Effects of 3′-OH and 5′-PO(4) Base Mispairs and Damaged Base Lesions on the Fidelity of Nick Sealing by Deinococcus radiodurans RNA Ligase
Deinococcus radiodurans RNA ligase (DraRnl) is the founding member of a family of end-joining enzymes encoded by diverse microbes and viruses. DraRnl ligates 3′-OH, 5′-PO(4) nicks in double-stranded nucleic acids in which the nick 3′-OH end is RNA. Here we gauge the effects of 3′-OH and 5′-PO(4) bas...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3993322/ https://ncbi.nlm.nih.gov/pubmed/24532777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00020-14 |
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