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Independence from Kinetoplast DNA Maintenance and Expression Is Associated with Multidrug Resistance in Trypanosoma brucei In Vitro
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast. To what extent this property relates to the mode of action of these compounds has remained largely unquantified. Here we show that sin...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3993240/ https://ncbi.nlm.nih.gov/pubmed/24550326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00122-14 |
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