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Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis

Ribosomopathies are a class of diseases caused by mutations that affect the biosynthesis and/or functionality of the ribosome. Although they initially present as hypoproliferative disorders, such as anemia, patients have elevated risk of hyperproliferative disease (cancer) by midlife. Here, this par...

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Bibliografiska uppgifter
Huvudupphovsmän: Sulima, Sergey O., Patchett, Stephanie, Advani, Vivek M., De Keersmaecker, Kim, Johnson, Arlen W., Dinman, Jonathan D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992666/
https://ncbi.nlm.nih.gov/pubmed/24706786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400247111
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