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Adaptive designs for clinical trials assessing biomarker-guided treatment strategies

BACKGROUND: The Biomarker Strategy Design has been proposed for trials assessing the value of a biomarker in guiding treatment in oncology. In such trials, patients are randomised to either receive the standard chemotherapy treatment or a biomarker-directed treatment arm, in which biomarker status i...

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Detalhes bibliográficos
Main Authors: Wason, J, Marshall, A, Dunn, J, Stein, R C, Stallard, N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992506/
https://ncbi.nlm.nih.gov/pubmed/24667651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.156
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