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Rapid Access to Spirocyclic Oxindole Alkaloids: Application of the Asymmetric Palladium-Catalyzed [3+2] Trimethylenemethane Cycloaddition

The marcfortines are complex secondary metabolites that show potent anthelmintic activity and are characterized by the presence of a bicyclo[2.2.2]diazaoctane fused to a spirooxindole. Herein, we report the synthesis of two members of this family. The synthesis of marcfortine B utilizes a carboxylat...

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Autori principali: Trost, Barry M., Bringley, Dustin A., Zhang, Ting, Cramer, Nicolai
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992010/
https://ncbi.nlm.nih.gov/pubmed/24083654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja409013m
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