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Enhanced Cell-Specific Ablation in Zebrafish Using a Triple Mutant of Escherichia Coli Nitroreductase

Transgenic expression of bacterial nitroreductase (NTR) facilitates chemically-inducible targeted cell ablation. In zebrafish, the NTR system enables studies of cell function and cellular regeneration. Metronidazole (MTZ) has become the most commonly used prodrug substrate for eliciting cell loss in...

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Bibliografiske detaljer
Main Authors: Mathias, Jonathan R., Zhang, Zhanying, Saxena, Meera T., Mumm, Jeff S.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992008/
https://ncbi.nlm.nih.gov/pubmed/24428354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/zeb.2013.0937
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