The mechanism of translation initiation on Type 1 picornavirus IRESs

Picornavirus Type 1 IRESs comprise five principal domains (dII–dVI). Whereas dV binds eIF4G, a conserved AUG in dVI was suggested to stimulate attachment of 43S ribosomal preinitiation complexes, which then scan to the initiation codon. Initiation on Type 1 IRESs also requires IRES trans-acting fact...

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Bibliografiske detaljer
Main Authors: Sweeney, Trevor R, Abaeva, Irina S, Pestova, Tatyana V, Hellen, Christopher U T
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990684/
https://ncbi.nlm.nih.gov/pubmed/24357634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201386124
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