Efficient Generation of Myostatin (MSTN) Biallelic Mutations in Cattle Using Zinc Finger Nucleases

Genetically engineered zinc-finger nucleases (ZFNs) are useful for marker-free gene targeting using a one-step approach. We used ZFNs to efficiently disrupt bovine myostatin (MSTN), which was identified previously as the gene responsible for double muscling in cattle. The mutation efficiency of bovi...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Luo, Junjie, Song, Zhiyuan, Yu, Shengli, Cui, Dan, Wang, Benli, Ding, Fangrong, Li, Song, Dai, Yunping, Li, Ning
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990601/
https://ncbi.nlm.nih.gov/pubmed/24743319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095225
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