Dexmedetomidine Reduces Isoflurane-Induced Neuroapoptosis Partly by Preserving PI3K/Akt Pathway in the Hippocampus of Neonatal Rats

Prolonged exposure to volatile anesthetics, such as isoflurane and sevoflurane, causes neurodegeneration in the developing animal brains. Recent studies showed that dexmedetomidine, a selective α2-adrenergic agonist, reduced isoflurane-induced cognitive impairment and neuroapoptosis. However, the me...

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Hlavní autoři: Li, Yujuan, Zeng, Minting, Chen, Weiqiang, Liu, Chuiliang, Wang, Fei, Han, Xue, Zuo, Zhiyi, Peng, Shuling
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990549/
https://ncbi.nlm.nih.gov/pubmed/24743508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093639
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