Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation

Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). Here, we sequenced the genome and performed an RNA-Seq-based analysis of the C...

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Main Authors: Janbon, Guilhem, Ormerod, Kate L., Paulet, Damien, Byrnes, Edmond J., Yadav, Vikas, Chatterjee, Gautam, Mullapudi, Nandita, Hon, Chung-Chau, Billmyre, R. Blake, Brunel, François, Bahn, Yong-Sun, Chen, Weidong, Chen, Yuan, Chow, Eve W. L., Coppée, Jean-Yves, Floyd-Averette, Anna, Gaillardin, Claude, Gerik, Kimberly J., Goldberg, Jonathan, Gonzalez-Hilarion, Sara, Gujja, Sharvari, Hamlin, Joyce L., Hsueh, Yen-Ping, Ianiri, Giuseppe, Jones, Steven, Kodira, Chinnappa D., Kozubowski, Lukasz, Lam, Woei, Marra, Marco, Mesner, Larry D., Mieczkowski, Piotr A., Moyrand, Frédérique, Nielsen, Kirsten, Proux, Caroline, Rossignol, Tristan, Schein, Jacqueline E., Sun, Sheng, Wollschlaeger, Carolin, Wood, Ian A., Zeng, Qiandong, Neuvéglise, Cécile, Newlon, Carol S., Perfect, John R., Lodge, Jennifer K., Idnurm, Alexander, Stajich, Jason E., Kronstad, James W., Sanyal, Kaustuv, Heitman, Joseph, Fraser, James A., Cuomo, Christina A., Dietrich, Fred S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990503/
https://ncbi.nlm.nih.gov/pubmed/24743168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004261
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