Co-regulation proteomics reveals substrates and mechanisms of APC/C-dependent degradation

Using multiplexed quantitative proteomics, we analyzed cell cycle-dependent changes of the human proteome. We identified >4,400 proteins, each with a six-point abundance profile across the cell cycle. Hypothesizing that proteins with similar abundance profiles are co-regulated, we clustered the p...

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Bibliographic Details
Main Authors: Singh, Sasha A, Winter, Dominic, Kirchner, Marc, Chauhan, Ruchi, Ahmed, Saima, Ozlu, Nurhan, Tzur, Amit, Steen, Judith A, Steen, Hanno
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989644/
https://ncbi.nlm.nih.gov/pubmed/24510915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201385876
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