Ultra Low-Dose IL-2 for GVHD prophylaxis after Allogeneic Hematopoietic Stem Cell Transplantation mediates Expansion of Regulatory T Cells Without Diminishing Anti-viral and Anti-leukemic Activity

PURPOSE: Graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (alloSCT) has been associated with low numbers of circulating CD4(+)CD25(+)FoxP3(+) regulatory T-cells(T(regs)). Because T(regs) express high levels of the IL-2 receptor, they may selectively expand in...

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Main Authors: Kennedy-Nasser, Alana A., Ku, Stephanie, Castillo-Caro, Paul, Hazrat, Yasmin, Wu, Meng-Fen, Liu, Hao, Melenhorst, Jos, Barrett, A. John, Ito, Sawa, Foster, Aaron, Savoldo, Barbara, Yvon, Eric, Carrum, George, Ramos, Carlos A, Krance, Robert A., Leung, Kathryn, Heslop, Helen E., Brenner, Malcolm K., Bollard, Catherine M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989436/
https://ncbi.nlm.nih.gov/pubmed/24573552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3205
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