Ganglioside GM3 depletion reverses impaired wound healing in diabetic mice by activating IGF-1 and insulin receptors

BACKGROUND: Ganglioside GM3 mediates adipocyte insulin resistance, but the role of GM3 in diabetic wound healing, a major cause of morbidity, is unclear. PURPOSE: Determine whether GM3 depletion promotes diabetic wound healing and directly activates keratinocyte insulin pathway signaling. RESULTS: G...

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Detalhes bibliográficos
Main Authors: Wang, Xiao-Qi, Lee, Sarah, Wilson, Heather, Seeger, Mark, Iordanov, Hristo, Gatla, Nandita, Whittington, Adam, Bach, Daniel, Lu, Jian-yun, Paller, Amy S
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989402/
https://ncbi.nlm.nih.gov/pubmed/24326453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2013.532
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