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Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers

Evidence suggests that the catabolic process of macroautophagy (autophagy hereafter) can either suppress or promote cancer. The essential autophagy gene ATG6/BECN1 encoding the Beclinl protein has been implicated as a haploinsufficient tumor suppressor in breast, ovarian and prostate cancers. The pr...

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Bibliografische gegevens
Hoofdauteurs: Laddha, Saurabh V, Ganesan, Shridar, Chan, Chang S., White, Eileen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989371/
https://ncbi.nlm.nih.gov/pubmed/24478461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0614
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