Deletion of the Complement C5a Receptor Alleviates the Severity of Acute Pneumococcal Otitis Media following Influenza A Virus Infection in Mice

There is considerable evidence that influenza A virus (IAV) promotes adherence, colonization, and superinfection by S. pneumoniae (Spn) and contributes to the pathogenesis of otitis media (OM). The complement system is a critical innate immune defense against both pathogens. To assess the role of th...

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Autors principals: Tong, Hua Hua, Lambert, Garrett, Li, Yong Xing, Thurman, Joshua M., Stahl, Gregory L., Douthitt, Kelsey, Clancy, Caitlin, He, Yujuan, Bowman, Andrew S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989264/
https://ncbi.nlm.nih.gov/pubmed/24740152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095160
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