Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions()

The novel guanidine compounds trans-[Pt(NH(2)Me)(2){NH=C(NHMe)NR}(2)](Cl)(2) (R = NEt(2) [7], NC(5)H(10) [8]) (trans-7,8) were synthesized by the nucleophilic addition of methylamine to dialkylcyanamide ligands of the push–pull nitrile complexes trans-[PtCl(2)(RCN)(2)] (R = NEt(2), NC(5)H(10)). In v...

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Hlavní autoři: Legin, Anton A., Jakupec, Michael A., Bokach, Nadezhda A., Tyan, Marina R., Kukushkin, Vadim Yu., Keppler, Bernhard K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989059/
https://ncbi.nlm.nih.gov/pubmed/24444821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2013.12.007
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