Oncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In trans

To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry. Early autophosphorylation sites map to regions flanking the kinase domain core, while sites within the activ...

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Detalhes bibliográficos
Main Authors: Plaza-Menacho, Iván, Barnouin, Karin, Goodman, Kerry, Martínez-Torres, Rubén J., Borg, Annabel, Murray-Rust, Judith, Mouilleron, Stephane, Knowles, Phillip, McDonald, Neil Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988870/
https://ncbi.nlm.nih.gov/pubmed/24560924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.01.015
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