Forebrain-Specific CRF Overproduction During Development is Sufficient to Induce Enduring Anxiety and Startle Abnormalities in Adult Mice

Corticotropin releasing factor (CRF) regulates physiological and behavioral responses to stress. Trauma in early life or adulthood is associated with increased CRF in the cerebrospinal fluid and heightened anxiety. Genetic variance in CRF receptors is linked to altered risk for stress disorders. Thu...

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Detalhes bibliográficos
Main Authors: Toth, Mate, Gresack, Jodi E, Bangasser, Debra A, Plona, Zach, Valentino, Rita J, Flandreau, Elizabeth I, Mansuy, Isabelle M, Merlo-Pich, Emilio, Geyer, Mark A, Risbrough, Victoria B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988544/
https://ncbi.nlm.nih.gov/pubmed/24326400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.336
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