Serpins Promote Cancer Cell Survival and Vascular Cooption in Brain Metastasis

Brain metastasis is an ominous complication of cancer, yet most cancer cells that infiltrate the brain die of unknown causes. Here we identify plasmin from the reactive brain stroma as a defense against metastatic invasion, and plasminogen activator (PA) inhibitory serpins in cancer cells as a shiel...

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Bibliografiska uppgifter
Huvudupphovsmän: Valiente, Manuel, Obenauf, Anna C., Jin, Xin, Chen, Qing, Zhang, Xiang H.-F., Lee, Derek J., Chaft, Jamie E., Kris, Mark G., Huse, Jason T., Brogi, Edi, Massagué, Joan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988473/
https://ncbi.nlm.nih.gov/pubmed/24581498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.040
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