Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations

Waist circumference (WC) and waist-to-hip ratio (WHR) are surrogate measures of central adiposity that are associated with adverse cardiovascular events, type 2 diabetes and cancer independent of body mass index (BMI). WC and WHR are highly heritable with multiple susceptibility loci identified to d...

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Asıl Yazarlar: Yoneyama, Sachiko, Guo, Yiran, Lanktree, Matthew B., Barnes, Michael R., Elbers, Clara C., Karczewski, Konrad J, Padmanabhan, Sandosh, Bauer, Florianne, Baumert, Jens, Beitelshees, Amber, Berenson, Gerald S., Boer, Jolanda M.A., Burke, Gregory, Cade, Brian, Chen, Wei, Cooper-Dehoff, Rhonda M., Gaunt, Tom R., Gieger, Christian, Gong, Yan, Gorski, Mathias, Heard-Costa, Nancy, Johnson, Toby, Lamonte, Michael J., Mcdonough, Caitrin, Monda, Keri L., Onland-Moret, N. Charlotte, Nelson, Christopher P., O'Connell, Jeffrey R., Ordovas, Jose, Peter, Inga, Peters, Annette, Shaffer, Jonathan, Shen, Haiqinq, Smith, Erin, Speilotes, Liz, Thomas, Fridtjof, Thorand, Barbara, Monique Verschuren, W. M., Anand, Sonia S., Dominiczak, Anna, Davidson, Karina W., Hegele, Robert A., Heid, Iris, Hofker, Marten H., Huggins, Gordon S., Illig, Thomas, Johnson, Julie A., Kirkland, Susan, König, Wolfgang, Langaee, Taimour Y., Mccaffery, Jeanne, Melander, Olle, Mitchell, Braxton D., Munroe, Patricia, Murray, Sarah S., Papanicolaou, George, Redline, Susan, Reilly, Muredach, Samani, Nilesh J., Schork, Nicholas J., Van Der Schouw, Yvonne T., Shimbo, Daichi, Shuldiner, Alan R., Tobin, Martin D., Wijmenga, Cisca, Yusuf, Salim, Hakonarson, Hakon, Lange, Leslie A., Demerath, Ellen W, Fox, Caroline S., North, Kari E, Reiner, Alex P., Keating, Brendan, Taylor, Kira C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Association Studies Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988452/
https://ncbi.nlm.nih.gov/pubmed/24345515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt626
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